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Nyren’s sequencing method earned the name “pyrosequencing” since it revolved around the production of pyrophosphate. At first, pyrosequencing could sequence only short DNA snippets, with a few nucleotides. In 1996, however, Nyren’s lab demonstrated sequencing of up to 15 bases by using a modified “A” nucleotide to reduce their signal-to-noise ratio.7 In 1998, they increased this to 34 bases by adding another enzyme, called apyrase, to the mix; apyrase degraded unincorporated nucleotides, removing the need for constant wash steps.

President Donald Trump has ordered all US government agencies to stop using Claude and other Anthropic services, escalating an already volatile feud between the Department of Defense and company over AI safeguards. Taking to Truth Social on Friday afternoon, the president said there would be a six-month phase out period for federal agencies, including the Defense Department, to migrate off of Anthropic's products.

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